Mike Belosevic, Ph.D., FRSC

Distinguished University Professor
CW-405 Biological Sciences
University of Alberta
11645 Saskatchewan Drive
Edmonton, AB T6G 2E9

Email: mike.belosevic@ualberta.ca

Research Interests:
My primary research interest is the immunobiology of host-parasite associations and my research goals have been to: (a) Describe and analyze the mechanisms of innate immunity to obligate intracellular and extracellular protozoan parasites in animals and humans; (b) Study the regulation of macrophage anti-microbial mechanisms in mammals and fish; and (c) Develop methods for detection and inactivation of protozoan parasites, prions and chemical pollutants in environmental samples.

Recent Publications:

Grayfer L. Belosevic M. Comparison of macrophage antimicrobial responses induced by type II interferons of the goldfish (Carasius auratus L.). Journal of Biological Chemistry 2010; 285:23537-23547.

Oladiran A, Belosevic M. Trypanosoma carassii calreticulin binds host complement component C1q and inhibits classical complement pathway-mediated lysis. Developmental and Comparative Immunology 2010; 34:396-405.

Hitchen SJ, Shostak AW, Belosevic M. Hymenolepis diminuta (Cestoda) induces changes expression of select genes of Tribolium confusum (Coleoptera). Parasitology Research 2009; 105:875-879.

Oladiran A, Belosevic M. Trypanosoma carassii hsp70 increases the expression of inflammatory cytokines and chemokines in macrophages of the goldfish (Carassius auratus L.). Developmental and Comparative Immunology 2009; 33: 1128-1136.

Li D, Craik SA, Smith DW, Belosevic M. Infectivity of Giardia lamblia cysts obtained from wastewater treated with ultraviolet light. Water Research 2009; 43:3037-3046.

Hanington PC, Tam J, Katzenback BA, Hitchen SJ, Barreda DR, Belosevic M. Development of macrophages of bony fish. Developmental and Comparative Immunology 2009; 33:411-429.

Li D, Craik SA, Smith DW, Belosevic M. The assessment of particle association and UV disinfection of wastewater using indigenous spore-forming bacteria. Water Research 2009; 43:481-489.

Wang T, Hanington PC, Belosevic M, Secombes CJ. Fish macrophage colony stimulating factor genes: diversified gene organizations and novel functions. Journal of Immunology 2008; 181:3310-3322.

Oladiran A, Hitchen SJ, Katzeback BA, Belosevic M. Biology of select zoonotic protozoan infections of domestic animals. UNESCO Encyclopedia of Life Support Systems 2008; (http://greenplanet.eolss.net/EolssLogn/InsLogin.aspx)

Katzenback BA, Plouffe DA, Haddad G, Belosevic M. Immunization with recombinant parasite beta-tubulin increases resistance of goldfish Carassius auratus (L.) to infection with Trypanosoma danilewskyi Laveran and Mesnil, 1904. Veterinary Parasitology 2008; 151:36-45.

Li D, Craik SA, Smith DW, Belosevic M. Survival of Giardia lamblia trophozoites after exposure to ultraviolet light. FEMS Microbiology Letters 2008; 278:56-61.