Andre G. Buret, Ph.D.

Professor, Associate Vice-President Research, University of Calgary
Dept. Biological Sciences,
Inflammation Research Network
University of Calgary,
Calgary, AB


Research interests:
Similar events characterize disease processes at mucosal sites, such as the intestine and the lungs. Diseases at these sites represent the most common cause of death in humans and other animal species world-wide. The overall aim of my research is to define microbial-host cell interactions in these systems, and how such interactions may affect gastrointestinal and pulmonary physiology, responsiveness, and inflammation, in an attempt to develop novel therapeutic strategies. Particular emphasis is given to research on the pathophysiology of intestinal Giardia infections.

Recent Publications:

Fisher C, Beatty JK, Duquette S, Morck DW, Lucas ML, Buret AG. (2013). Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages: Inhibition of CXCL-8 Secretion, Induction of Apoptosis, and Promotion of Efferocytosis. Antimicrob. Ag. Chemother. 57(3): 1385-1393

Buret AG, Bhargava A. (2013) Modulatory mechanisms of enterocyte apoptosis by viral, bacterial, and parasitic pathogens. Critical Rev. in Microbiology (in press).

O’Hara JR, Feener TD, Fuscher CD, Buret AG. (2012) Campylobacter jejuni disrupts protective TLR9 signaling in colonic epithelial cells and increases the severity of DSS-induced colitis in mice. Infect. Immun. 80(4):1563-1571

LaPointe TK, Buret AG. (2012) Interleukin-18 facilitates neutrophil transmigration via myosin light chain kinase-dependent disruption of occludin, without alerting epithelial permeability. Am. J. Physiol. (Gastrointestinal Liver Physiol) 302(3):G343-G351

O’Connor PM, LaPointe TK, Jackson S, Beck PB, Jones NL, Buret AG. (2011) H. pylori activates calpain via TOLL-like receptor 2 to disrupt adherens junctions in human gastric epithelial cells. Infect. Immun 79(10): 3887-3894.

Cotton J, Beatty J, Buret AG. (2011) Host-parasite interactions in giardiasis. Int. J. Parasitol. (41):925-933.

Flynn AN, Wang A, McKay DM, Buret AG. (2011) Apoptosis-inducing factor contributes to epithelial cell apoptosis induced by enteropathogenic Escherichia coli. Can. J. Physiol. Pharmacol. 89(2):143-148.

Fisher C, Beatty JK, Zvaigne CG, Morck DW, Lucas ML, Buret AG. (2011) Tulathromycin inhibits NFkB signaling via the induction of caspase-3-dependent apoptosis in bovine neutrophils. Antimicr. Ag. Chemother. (in press, January issue)

LaPointe TK, O’Connor PM, Jones NL, Menard D, Buret AG. (2010) Interleukin-1 receptor phosphorylation activates Rho kinase to disrupt human gastric tight junctional claudin-4 during Helicobacter pylori infection. Cell. Micro. 12(5): 692-703.

Kalischuk LD, Buret AG. (2010) A role for Campylobacter-jejuni induced enteritis in inflammatory bowel disease? Am. J. Physiol. 298:G1-G9.

Lamb-Rosteski JM, Kalischuk LD, Inglis GD, Buret AG. (2008) Epidermal growth factor inhibits Campylobacter jejuni-induced claudin-4 disruption, loss of epithelial barrier function, and Escherichia coli translocation. Infect. Immun. 76(8): 3390-3398.

Yu LCH, Huang C-Y, Kuo W-T, Sayer H, Turner JR, Buret AG. (2008) SGLT-1 –mediated glucose uptake protects human intestinal epithelial cells against Giardia duodenalis –induced apoptosis. Int. J. Parasitol. 38: 923-934

Buret AG. (2008) Pathophysiology of enteric infections with Giardia duodenalis. Parasite 15:261-266

Buret AG, Cotton J. (2011) Pathophysiological processes and clinical manifestations of giardiasis, In: LUJAN, H.D., SVARD, S., Giardia and giardiasis, Springer-Verlag, Wien and New York (in press).

Buret AG. (2011) The effects of microbes on enterocyte apoptosis, (in press); In: Life and death of the intestinal epithelial cell (P.H. Vachon, Ed.) (in press)